图书介绍

医药化学2025|PDF|Epub|mobi|kindle电子书版本百度云盘下载

（英）帕特里克（PatrickG.）著著
出版社：北京：科学出版社
ISBN：7030109627
出版时间：2003
标注页数：278页
文件大小：19MB
文件页数：287页
主题词：预防医学

PDF下载

点此进入-本书在线PDF格式电子书下载【推荐-云解压-方便快捷】直接下载PDF格式图书。移动端-PC端通用
种子下载[BT下载速度快]温馨提示：（请使用BT下载软件FDM进行下载）软件下载地址页直链下载[便捷但速度慢] [在线试读本书] [在线获取解压码]

点击复制MD5值：8ef07ce94bbc68877605022b6202c233

下载说明

医药化学PDF格式电子书版下载

下载的文件为RAR压缩包。需要使用解压软件进行解压得到PDF格式图书。

点击复制85GB完整离线版磁力链接到迅雷FDM等BT下载工具进行下载详情点击-查看共享计划

建议使用BT下载工具Free Download Manager进行下载,简称FDM(免费,没有广告,支持多平台）。本站资源全部打包为BT种子。所以需要使用专业的BT下载软件进行下载。如BitComet qBittorrent uTorrent等BT下载工具。迅雷目前由于本站不是热门资源。不推荐使用！后期资源热门了。安装了迅雷也可以迅雷进行下载！

（文件页数要大于标注页数，上中下等多册电子书除外）

注意：本站所有压缩包均有解压码： 点击下载压缩包解压工具

图书目录

Section A-The science of medicinal chemistry1

A1 Introduction1

A2 From concept to market4

Section B-Drug targets7

B1 Enzymes7

B2 Receptors13

B3 Carrier proteins24

B4 Structural proteins27

B5 Nucleic acids29

B6 Lipids35

B7 Carbohydrates38

Section C-Pharmacokinetics41

C1 Pharmacokinetics41

C2 Drug absorption42

C3 Drug distribution45

C4 Drug metabolism48

C5 Drug excretion51

C6 Drug administration54

C7 Drug dosing58

Section D-Biological testing and bioassays61

D1 Testing drugs61

D2 Testing drugs in vitro62

D3 Testing drugs in vivo70

Section E-Drug discovery75

E1 The lead compound75

E2 Natural sources of lead compounds77

E3 Synthetic sources of lead compounds82

F1 Synthetic considerations85

Section F-Synthesis85

F2 Stereochemistry90

F3 Combinatorial synthesis100

Section G-Structure-activity relationships105

G1 Definition of structure-activity relationships105

G2 Binding interactions107

G3 Functional groups as binding groups110

G4 The pharmacophore120

G5 Quantitative structure-activity relationships125

H1 Aims of drug design141

Section H-Target orientated drug design141

H2 Computer aided drug design143

H3 Simplification of complex molecules148

H4 Conformational restraint151

H5 Extra binding interactions155

H6 Enhancing existing binding interactions160

Section I-Pharmacokinetic orientated drug design167

I1 Drug solubility167

I2 Drug stability171

J1 Patenting and chemical development177

Section J-Patenting and manufacture177

J2 Optimization of reactions181

J3 Scale-up issues188

J4 Process development193

J5 Specifications197

Section K-Preclinical testing and clinical trials203

K1 Toxicology203

K2 Pharmacology and pharmaceutical chemistry205

K3 Drug metabolism studies207

K4 Clinial trials212

K5 Regulatory affairs216

Section L-Case study：inhibitors of EGF-receptor kinase221

L1 Epidermal growth factor receptor221

L2 Testing procedures224

L3 From lead compound to dianilino-phthalimides226

L4 Modeling studies233

L5 4-(Phenylamino)pyrrolopyrimidines239

L6 Pyrazolopyrimidines241

Section M-History of medicinal chemistry245

M1 The age of herbs,potions and magic245

M2 The nineteenth century247

M3 A fledgling science(1900-1930)251

M4 The dawn of the antibacterial age(1930-1945)254

M5 The antibiotic age(1945-1970s)258

M6 The age of reason(1970s to present)266