化学传感器：仿真与建模 第5卷 电化学传感器 下 英文影印版2025|PDF|Epub|mobi|kindle电子书版本百度云盘下载

化学传感器：仿真与建模 第5卷 电化学传感器 下 英文影印版PDF格式电子书版下载

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PART 3:ELECTROCHEMICAL BIOSENSORS251

7 NANOMATERIAL-BASED ELECTROCHEMICAL BIOSENSORS&N.Jaffrezic-Renault251

1 Introduction251

2 Nanomaterials:Fabrication,Chemical and Physical Properties252

2.1 Conducting Nanomaterials252

2.2 Nonconducting Nanomaterials:Magnetic Nanoparticles254

3 Conception and Modeling of Amplification Effect in Nanomaterial-Based Enzyme Sensors255

3.1 AuNPs-Based Amperometric Sensors255

3.2 CNT-Based Amperometric Sensors258

3.3 MNP-Based Amperometric Biosensors262

3.4 Potentiometric Sensors265

3.5 Conductometric and Impedimetric Biosensors265

4 Conception and Modeling of Amplification Effect in Nanomaterial-Based Immunosensors267

4.1 AuNP-Based Amperometric Immunosensors267

4.2 AuNP-Based Potentiometric Sensors272

4.3 Impedimetric Sensors273

4.4 Conductometric Sensors276

5 Conception and Modeling of Amplification Effect in Nanomaterial-Based DNA Biosensors277

5.1 Amperometric Sensors277

5.2 Impedimetric Sensors283

6 Conclusion284

References285

8 IoN-SENSITIVE FIELD-EFFECT TRANSISTORS WITH NANOSTRUCTURED CHANNELS AND NANOFARTICLE-MODIFIED GATE SURFACES:THEORY,MODELING,AND ANALYSIS&V.K.Khanna295

1 Introduction295

2 Structural Configurations of the Nanoscale ISFET297

2.1 The Nanoporous Silicon ISFET297

2.2 The CNT ISFET298

2.3 The Si-NW ISFET299

3 Physics of the Si-NW Biosensor299

3.1 Basic Principle299

3.2 Analogy with the Nanocantilever300

3.3 Preliminary Analysis of Micro-ISFET Downscaling to Nano-ISFET301

3.4 Single-Gate and Dual-Gate Nanowire Sensors304

3.5 Energy-Band Model of the NW Sensor305

4 Nair-Alam Model of Si-NW Biosensors307

4.1 The Three Regions in the Biosensor307

4.2 Computational Approach308

4.3 Effect of Nanowire Diameter(d)on Sensitivity at Different Doping Densities,with Air as the Surrounding Medium310

4.4 Effect of Nanowire Length(L)on Sensitivity at Different Doping Densities,with Air as the Surrounding Medium310

4.5 Effect of the Fluidic Environment310

4.6 Overall Model Implications315

5 pH Response of Silicon Nanowires in Terms of the Site-Binding and Gouy-Chapman-Stern Models316

6 Subthreshold Regime as the Optimal Sensitivity Regime of Nanowire Biosensors321

7 Effective Capacitance Model for Apparent Surpassing of the Nernst Limit by Sensitivity of the Dual-Gate NW Sensor324

8 Tunnel Field-Effect Transistor Concept326

9 Role of Nanoparticles in ISFET Gate Functionalization328

9.1 Supportive Role of Nanoparticles328

9.2 Direct Reactant Role of Nanoparticles330

10 Neuron-CNT(Carbon Nanotube)ISFET Junction Modeling332

11 Conclusions and Perspectives334

Dedication335

Acknowledgments335

References335

9 BIOSENSORS:MODELING AND SIMULATION OF DIFFUSION-LIMITED PROCESSES&L.Rajendran339

1 Introduction339

1.1 Enzyme Kinetics339

1.2 Basic Scheme of Biosensors340

1.3 The Nonlinear Reaction-Diffusion Equation and Biosensors340

1.4 Types of Biosensors342

1.5 Michaelis-Menten Kinetics343

1.6 Non-Michaelis-Menten Kinetics343

1.7 Importance of Modeling and Simulation of Biosensors344

2 Modeling of Biosensors345

2.1 Michaelis-Menten Kinetics and Potentiometric Biosensors345

2.2 Michaelis-Menten Kinetics and Amperometric Biosensors346

2.3 Michaelis-Menten Kinetics and Amperometric Biosensors for Immobilizing Enzymes348

2.4 Michaelis-Menten Kinetics and the Two-Substrate Model349

2.5 Non-Michaelis-Menten Kinetics353

2.6 Other Enzyme Reaction Mechanisms356

2.7 Kinetics of Enzyme Action361

2.8 Trienzyme Biosensor362

3 Microdisk Biosensors363

3.1 Introduction363

3.2 Mathematical Formulation of the Problem364

3.3 First-Order Catalytic Kinetics366

3.4 Zero-Order Catalytic Kinetics370

3.5 For All Values of KM372

3.6 Conclusions373

4 Microcylinder Biosensors373

4.1 Introduction373

4.2 Mathematical Formulation of the Problem374

4.3 Analytical Solutions of the Concentrations and Current376

4.4 Comparison with Limiting Case of Rijiravanich's Work378

4.5 Discussion379

4.6 Conclusions381

4.7 PPO-Modified Microcylinder Biosensors382

5 Spherical Biosensors383

5.1 Simple Michaelis-Menten and Product Competitive Inhibition Kinetics383

5.2 Immobilized Enzyme for Spherical Biosensors385

5.3 Conclusion386

Appendix:Various Analytical Schemes for Solving Nonlinear Reaction Diffusion Equations386

A．Basic Concept of the Variational Iteration Method386

B．Basic Concept of the Homotopy Perturbation Method387

C．Basic Concept of the Homotopy Analysis Method388

D．Basic Concept of the Adomian Decomposition Method391

References392

INDEX399