风湿病学 第2版 英文2025|PDF|Epub|mobi|kindle电子书版本百度云盘下载

风湿病学 第2版 英文PDF格式电子书版下载

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Chapter 1 Scientific Basis of Rheumatic DiseasesInnate Immunity3

Innate Versus Acquired Immunity3

Specific,or Acquired,Immunity6

Immune Cell-Surface Markers7

B Cells7

Autoantibody Production14

T Cells15

Inflammation28

Inflammatory Cells28

Neutrophils28

Macrophages29

Eosinophils29

Mast Cells29

Basophils29

Adhesion Molecules30

Cytokines and their Receptors32

Mediators of the Acute-Phase Response32

T-Cell Cytokines34

Cellular Growth Factors36

Mediators of Inflammation37

Collagen41

Structure and Biology41

Types of Collagen42

Collagen Metabolism44

Annotated Bibliography44

Chapter 2 Methodologies of Basic Research and Clinicol InvestigationMethodologles of Basic Research49

Elisa49

Immunofluorescence50

Southern Blotting50

Northern Blotting51

Western Blotting51

Polymerase Chain Reaction51

Animal Models52

Oral Tolerance53

Transgenic and Gene Knockout Animals54

Gene Therapy55

Monoclonal Antibodies and Antibody Technology56

Fluorescence Activated Cell Sorting57

Methodology in Clinical Studies58

Diagnostic Testing60

Statistics62

Meta-Analysis62

Health Status Measurements62

Annotated Bibllography63

Chapter 3 Diagnostic Imaging of Rheumatologic DiseaseIntroduction65

Plain Radiographs65

Ultrasonography67

Computed Tomography68

Skeletal Scintigraphy68

Magnetic Resonance Imaging70

Summary73

Annotated Bibllography73

Chapert 4 Therapies For Rheumatic DiseaseNonsteroidal Anti-Inflammatory Drugs74

Mechanisms of Action74

Pharmacology76

Toxic Effects78

Corticosteroids83

Pharmacology83

Mechanism of Action84

Effects of Corticosteroids84

Pituitary-Adrenal Cortical Function84

Efficacy and Utility in Specific Rheumatic Diseases85

Antirheumatic Drugs87

Purine Analogues87

D-Penicillamine89

Gold Compounds89

Antimalarial Drugs90

Sulfasalazine91

Methotrexate91

Immunomodulators93

Cyclophosphamide93

Chlorambucil94

Cyclosporine94

Investigational Agents95

Anti-T-Cell Therapy96

Cytokine-Directed Therapy96

Miscellaneous Drugs97

Colchicine97

Allopurinol98

Analgesics99

Capsaicin99

Acetaminophen100

Antidepressants100

Opioid Analgesics100

Tramadol101

Annotated Bibliography101

Chapter 5 Rheumatoid Arthritis107

Pathogenesis107

Epidemiology109

Classification Criteria109

Clinical Features110

Clinical Presentation110

Cervical Spine111

Pleuropulmonary Manifestations111

Cardiac Manifestations113

Feltv's Syndrome and Pseudo-Felty's Syndrome113

RheumatoidNodules113

Malignancy114

Prognosis114

Therapy115

Background115

General Approach to Treatment115

Drug Therapy116

Surgery117

Outcome Assessment117

Annotated Bibliography119

Appendix 1121

Chapter 6 Spondyloarthropathies126

A Wider Clinical Spectrum126

Etiopathogenesis126

Ankylosing Spondylitis129

Pathology130

Clinical Features130

Diagnosis131

Differential Diagnosis133

Management133

Reactive Arthritis(Reiter's Syndrome)134

Epidemiology134

Clinical Featurs134

Radiologic Findings136

Diagnosis136

Management137

Psoriatic Arthritis138

Diagnosis138

Management139

Enteropathic Arthritis139

Annotated Bibliography139

Chapter 7 Systemic Lupus Erythematosus',Antiphospholipid syndrome,and Sj？gren's SyndromeSystemic Lupus Erythematosus142

Pathogenesis142

Epidemiology146

Criteria and Approach to Diagnosis147

Clinical Features147

Clinical Course and Prognosis151

Treatment151

Antiphospholipid Syndrome153

Case Study153

Pathogenesis154

Clinical Features154

Diagnostic Tests155

Treatment155

Sj？gren's Syndrome156

Pathogenesis156

Clinical Features157

Diagnosis and Classification158

Treatment158

Annotated Bibliography159

Chapter 8 Vasculitis161

Pathogenesis161

C？nical and Pathologic Descriptions163

Hypersensitivity Vasculitis163

Sch？nlein-Henoch Purpura163

Central Nervous System Vasculitis163

Polyarteritis Nodosa164

Microscopic Polyangiitis164

Wegener's Granulomatosis164

Giant Cell Arteritis165

Polymyalgia Rheumatica166

Takayasu's Arteritis166

Churg-Strauss Vasculitis166

Mixed Cryoglobulinemia166

Treatment167

Annotated Bibliography167

Chapter 9 Scleroderma and Inflammatory MyopathiesScleroderma169

Epidemiology169

Pathogenesis169

Clinical Features170

Treatment173

Other Diseases with Skin Sclerosis174

Inflammatory Myopathies174

Epidemiology174

Pathophysiology175

Differential Diagnosis and Evaluation178

Polymyositis and Dermatomyositis179

Inclusion Body Myositis180

Diagnostic Testing180

Treatment181

Annotated Bibliography182

Chapter 10 Pediatric Rheumatic DiseasesJuvenile Rheumatoid Arthritis185

Incidence and Pathophysiology185

Onset Subtypes185

Evaluation of Children with Jra188

Management of Chronic Arthritis189

Nonsteroidal Anti-Inflammatory Drugs189

Corticosteroids189

Slow-Acting Antirheumatic Drugs190

Differential Diagnosis of Childhood Arthritis190

Mechanical Disorders190

Acute and Chronic Infections190

Malignancy190

Juvenile Spondyloarthropathies191

Inflammatory Disorders192

Noninfectious Arthritis192

Sch？nlein-Henoch Purpura192

Kawasaki Disease192

Systemic Lupus Erythematosus192

Neonatal Lupus Syndrome192

Juvenile Dermatomyositis192

Psychogenic Rheumatism193

Annotated Bibliography193

Chapter 11 Infection and Arthritis195

Nongonococcal Septic Arthritis195

Epidemiology195

Pathophysiology195

Pathogenic Organisms196

Risk Factors196

Clinical Manifestations197

Diagnosis197

Prostheric Joint Infections198

Disseminated Gonococcal Arthritis199

Treatment of Disseminated Gonococcal Infection199

Treatment and Prognosis199

Mycobacterial Arthritis201

Fungal Arthritis201

Hiv and Aids201

Arthralgia201

Fibromyalgia Syndrome201

Reiter's Syndrome201

Psoriatic Arthritis202

Nonspecific Oligoarthritis202

Septic Arthritis202

Myositis202

Sj？gren's-Like Syndrome202

Vasculitis203

Autoantibodies203

Hepatitis B and Parvovirus204

Lyme Disease204

Epidemiology204

Clinical Features205

The Three Stages of Lyme Disease205

Confirming The Diagnosis With Testing206

Treatment207

Prevention209

Annotated Bibliography209

Chapter 12 Other Arthropathies211

Hemophilic Arthropathy211

Sickle Cell Disease211

Poems212

Pigmented Villonodular Synovitis212

Hypertrophic Osteoarthropathy213

Amyloid Arthropathies213

Al Amyloid214

Aa Amyloid214

Sarcoidosis214

Annotated Bibliography214

Chapter 13 Rheumatic Disease and ReproductionIntroduction216

Sexuality and Arthritis216

Contraception217

Pregnancy218

Physiologic Changes of Normal Pregnancy218

Drug Therapy and Reproduction219

Pregnancy and Specific Rheumatic Diseases220

Lactation224

Musculoskeletal Disorders224

Annotated Bibliography225

Chapter 14 Crystal Disorders226

Crystal Identiffcation226

Gout226

Etiopathogenesis of Hyperuricemia226

Pathophysiology of Gouty Arthritis228

Polyarticular Gout228

Gout in Elderly Persons228

Precocious Familial Gout229

Drug-Induced Hyperuricemia and Gout229

Risk Factors for Acute Gout229

Gout as a Risk Factor for Coronary Disease229

Hyperuricemic Treatment229

Treatment of Acute Gout229

Treatment to Lower Serum Urate230

Calcium Pyrophosphate Dihydrate Deposition Disease230

Pathophysiology230

Familial(Hereditary)Articular Chondrocalcinosis231

Secondary Calcium Pyrophosphate Dihydrate Disease231

Hydroxyapatite (Basic Calcium Phosphate Disease)231

Other Crystals Associated with Arthritis232

Joint Problems Associated with Chronic Renal Failure232

Crystal-Induced Arthritis232

Septic Arthritis233

B2-Microglobutin Amyloidosis233

Osteonecrosis235

Annotated Bibliography235

Chapter 15 Bone and Cartilage DisordersOsteoarthritis237

Epidemiology237

Classification238

The Components of Cartilage238

Tissue Charges240

Clinical Manifestations240

Diagnosis241

Treatment241

Paget's Disease of Bone242

Etiology242

Histopathology242

Biochemical Markers242

Clinical Features244

Therapy244

Osteoporesis245

Differential Diagnosis245

Pathophysiology245

Clinical Manifestations247

Diagnosis249

Management251

Summary254

Annotated Bibliography254

Chapter 16 Soft Tissue and Regional Pain DisordersAxial Pain Syndromes:Back and Neck Pain258

Mechanism258

Clinical Evaluation259

Treatment265

Sports Medicine266

Upper Extremities267

The Shoulder267

The Elbow271

The Wrist271

Lower Extremities271

The Hip271

Ischiogluteal Bursitis272

The Knee272

The Foot276

Reflex Sympathetic Dystrophy Syndrome279

Fibromyalgia Syndrome280

Epidemiology280

Natural History280

Diagnosis280

Association with Other Conditions281

Pathophysiology281

Association with Psychological Disturbance281

Studies of Regional Cerebral Blood Flow283

Treatment283

Annotated Bibliography285

Chapter 17 Total Joint Replacement and ArthroscopyTotal Joint Replacement288

Indications and Contraindications288

Preoperative Planning288

Postoperative Care289

Total Hip Replacement289

Total Knee Replacement295

Total Shoulder Replacement298

Total Elbow Replacement298

Total Ankle Replacement299

F？ture Directions for Total Joint Replacement299

Arthroscopy300

The Knee Joint300

The Shoulder Joint301

Elbow,Wrist,and Hip301

Complications of Arthroscopy302

Annotated Bibliography302

Chapter 18 Rehabilitation305

Introduction305

Methods of Rehabilitation305

Exercise305

Rest and Splinting305

Thermal Therapy306

Transcutaneous Electrical Nerve Stimulation306

Mobilization Techniques306

Spa Therapy306

Aids and Appliances307

Rehabilitation of Specific Joints307

Knee307

Ankle/Foot307

Shoulder307

Elbow308

Hand/Wrist308

Cervical Spine308

Annotated Bibliography308

Self-Assessment Test311

General Instructions311

Multiple-Choice Questions312

Answers and Critiques349

Instructions for Scoring409

Normal Laboratory Values410

Index412