Metabolic Inhibitorsl A Comprehensive Treatise Volume IV2025|PDF|Epub|mobi|kindle电子书版本百度云盘下载

Metabolic Inhibitorsl A Comprehensive Treatise Volume IVPDF格式电子书版下载

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CHAPTER 1 Allosteric Inhibitors＆R．W．MILLER1

Ⅰ．Introduction2

Ⅱ．Limiting Models for Allosteric Inhibition3

Ⅲ．Methods That Probe Mechanisms of Allosteric Inhibition13

Ⅳ．Variation of Allosteric Properties among Source Organisms16

Ⅴ．Classes of Allosteric Inhibitors17

Ⅵ．Allosteric Inhibition of Specific Enzymes23

Ⅶ．Allosteric Inhibition in Enzyme Complexes and Membrane Systems38

References40

CHAPTER 2 Amino Acid Hydroxylase inhibitors＆EDITH G．McGEER and PATRICK L．McGEER45

Ⅰ．Introduction45

Ⅱ．Properties of the Enzymes46

Ⅲ．In Vitro Inhibitors of the Hydroxylases56

Ⅳ．In Vivo Inhibitors of the Hydroxylases71

Ⅴ．Indirect Mechanisms of Inhibition84

Ⅵ．Conclusion89

References90

CHAPTER 3 Inhibitors of Amino Acid Activation＆ROBERT B．LOFTFIELD107

Ⅰ．Introduction107

Ⅱ．Noncompetitive Inhibitors111

Ⅲ．Competitive Inhibitors114

Ⅳ．Conclusion123

References127

CHAPTER 4 Inhibitors of Protein Synthesis＆C．T．CASKEY131

Ⅰ．Introduction131

Ⅱ．Protein Biosynthesis132

Ⅲ．Inhibitors of Peptide Chain Initiation139

Ⅳ．Inhibitors of Peptide Chain Elongation144

Ⅴ．Inhibitors of Peptide Chain Termination163

Ⅵ．Premature Peptide Chain Termination165

Ⅶ．Other Inhibitors167

Ⅷ．Summary169

References170

CHAPTER 5 Inhibition of Photosynthesis＆N．E．GOOD and S IZAWA179

Ⅰ．Introduction180

Ⅱ．The Overall Mechanism of Photosynthes＇s180

Ⅲ．Light-Dependent Reactions of Chloroplast Lamellae181

Ⅳ．Partial Reactions of Photosynthesis in Isolated Chloroplast Lamellae184

Ⅴ．Inhibitions of Electron Transport and Phosphorylation in Chloroplast Lamellae185

Ⅵ．Inhibition of the Fixation and Reduction of Carbon Dioxide201

Ⅶ．Photorespiration and the Inhibition of Photosynthesis by Oxygen204

Ⅷ．Indirect Inhibitions and the Physiological Control of Photosynthesis206

Ⅸ．Conclusion209

References210

CHAPTER 6 Inhibitors of Blood-Clotting Mechanisms＆PETER G．BARTON and E．THYE YIN215

Ⅰ．Introduction216

Ⅱ．Inhibitors of Enzyme Action231

Ⅲ．Inhibitors of Coagulant Protein Biosynthesis260

Ⅳ．Hereditary Inhibitors265

Ⅴ．Acquired Circulating Anticoagulants267

Ⅵ．Fibrinogen Degradation Products272

Ⅶ．Inhibitors of Lipids and Lipoproteins276

Ⅷ．Inhibitors of Intravascular Coagulation and Thrombosis280

Ⅸ．The Role of Heparin in Blood Coagulation282

Ⅹ．Concluding Remarks284

References289

CHAPTER 7 Inhibitors of Fatty Acid Oxidation and the Pathway of Fatty Acid Biosynthesis from Glucose＆I．B．FRITZ and M．HALPERIN311

Ⅰ．Fatty Acid Oxidation311

Ⅱ．Inhibition of Pathways of Fatty Acid Synthesis321

Ⅲ．Concluding Comments340

References342

CHAPTER 8 Inhibitors of Enzymes of Phospholipid and Sphingolipid Metabolism＆SHIMON GATT349

Ⅰ．Introduction350

Ⅱ．Phospholipid Hydrolases351

Ⅲ．Glycosphingolipid Hydrolases361

Ⅳ．Synthesis of the Glycerophosphatides365

Ⅴ．Synthesis of Phospho- and Glycosphingolipids369

Ⅵ．Metabolism of the Sphingosine Bases372

Ⅶ．Summary and Conclusions372

References383

CHAPTER 9 Inhibitors and Activators of Enzymes Regulating the Cellular Concentration of Cyclic AMP＆SHAIL K．SHARMA389

Ⅰ．Introduction389

Ⅱ．Distribution，Subcellular Location，Purification，and Properties of Adenyl Cyclase and Cyclic AMP Phosphodiesterase391

Ⅲ．Regulation of Intracellular Levels of Cyclic AMP395

Ⅳ．Regulation of Cyclic AMP Formation in Cells in Culture419

Ⅴ．Adenyl Cyclase and Phosphodiesterase in Relation to Age420

Ⅵ．Role of Lipids in the Activation of Adenyl Cyclase by Hormones421

Ⅶ．Modification of Adenyl Cyclase in Various Physiological and Pathological Conditions421

Ⅷ．Concluding Remarks422

References423

AUTHOR INDEX435

SUBJECT INDEX487